Head of Medicinal Chemistry

We are seeking a dynamic, entrepreneurial, innovative Head of Medicinal Chemistry to lead our drug discovery efforts. The successful candidate will be a strategic leader with a proven track record in drug discovery and development, from hit identification to clinical candidate selection to clinical development. This is an opportunity to make a significant impact on Calico’s mission to develop novel therapeutics that address age-related diseases and build a key functional area within the organization.

Responsibilities:

• Build and lead a high-performing medicinal chemistry team, augmented by external contract research organizations (CROs) as needed
• Collaboratively work with internal stakeholders to identify, recommend, and implement drug discovery strategies in a modality agnostic manner
• Oversee the design, synthesis, and optimization of small molecule programs
• Partner with biology, pharmacology, and development teams to translate biological insights into actionable chemical strategies
• Define roles and responsibilities within medicinal chemistry and program teams, ensuring efficient project management and optimal allocation of resources to support drug discovery objectives
• Use analytical and computational tools to make data-informed decisions in compound design and optimization, helping streamline drug discovery efforts
• Contribute to regulatory documentation and submissions by providing chemistry expertise, including data for IND and NDA filings
• Collaborate with IP counsel to shape and define medicinal chemistry strategies
• Stay abreast of the latest advancements in medicinal chemistry, identifying opportunities for external partnerships, collaborations, and integration of new technologies

Position Requirements:

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or a related field
• Minimum of 15 years of experience in medicinal chemistry within large and small pharmaceutical or biotech industry, with at least 5 years in a leadership role
• Experience managing activities at a biotech CRO preferred
• Demonstrated expertise in small molecule drug discovery, SAR studies, and lead optimization
• High level knowledge of current medicinal chemistry enabling technologies including: HTE, parallel synthesis, fragment screening including covalent strategies, DNA encoded libraries, TPD/induced proximity, AI/ML/generative chemistry
• Strong record of medicinal chemistry patent applications and peer review publications
• Proven track record of advancing compounds from discovery through clinical stages
• Exceptional leadership and team-building skills, with a collaborative mindset and the ability to mentor and develop scientific talent
• Excellent communication and presentation skills, with the ability to convey complex scientific concepts to diverse audiences
• Must be willing to work onsite at least 4 days a week

The estimated base salary range for this role is $315,000 – $345,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.