DMPK Senior Scientist / Lead Scientist and Project Representative

We are keen to recruit an experienced and highly motivated scientist to join the DMPK team at Nxera Pharma, based in Cambridge. As a member of the DMPK team, you will be responsible for providing expertise to multidisciplinary pre-clinical drug discovery projects, applying your knowledge and technical expertise to quantitatively characterise the ADME/PK and pharmacodynamics of drug candidates to ensure the delivery of high quality drug candidates to the clinic.This is an exciting position, leveraging our NxWave platform to support structure-based computational design in drug discovery projects and develop novel methodology/workflows for wider utility.

Responsibilities

In this role, the successful candidate will be responsible for:

The design of in vitro ADME and in vivo PK experiments
Interpretation and communication of ADME/PK data to drug discovery projects to aid effective drug design and molecule optimization
Highlight any potential risks within a chemical series and design appropriate strategies to mitigate
Contribute to the design of in vivo efficacy studies to ensure high quality data are generated for PKPD modelling
Characterise the DMPK and PKPD properties of molecules that underpin human PK predictions in order to make early assessment of dose
Play a vital role along with Safety to provide early insight into safety margins and risk of DILI.
Fully characterize molecules to support transition into development

Required:

• Educated to at least degree level with ideally 3+ years’ relevant experience in lead optimisation, candidate profiling, preclinical development
• Good technical knowledge of ADME/PK principles and good understanding of the relationship between PhysChem properties and drug design
• Familiar with methods for performing human PK predictions.
• Proven track record of problem solving and demonstration of critical thinking.
• Excellent interpersonal, oral and written communication skills and ability to work in a matrix environment with team members having diverse professional backgrounds
• Comfortable working in a fast-paced dynamic environment across multiple projects with tight deadlines and evolving priorities

Desirable:

• Experience of PBPK modelling software such as GatroPlus would be ideal but not a requirement as training can be provided
• Experience gained across multiple therapeutic areas would be an advantage and may include Metabolic, CNS, Immuno, GI disorders.
• Experience of Phoenix/WinNonLin PK analysis software.

Other information

What’s in it for you?

• State-of-the-art R&D centre located in the heart of the Cambridge science cluster· Competitive compensation package including discretionary cash bonuses
• Eligible for grants of Restricted Stock Units
• 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year
• Enhanced employer contribution to pension
• Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement
• Health and wellbeing benefits including a subsidised individual gym membership
• Income protection to cover long term absences due to ill health
• Group Death in Service equal to 4x basic annual salary.

Applications should include a CV and covering letter, providing a short description of the background of your interest in the role.