DMPK Lead, Lausanne

Your impact

At Isomorphic Labs, DMPK Leads drive the DMPK strategy of drug discovery projects to deliver high quality clinical candidates whilst using and contributing to the optimisation of state-of-the-art computational and AI ADME models.

As part of the Drug Design and Medical Research team and through close collaboration with the Technology teams, you will be supporting the business alongside world leading AI/ML Drug Design Platform teams. You will collaborate to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design projects.

If you are a skilled and ambitious scientist looking to take the next step in your career, joining the Isomorphic Labs now will lift you out of your comfort zone and provide you with an amazing opportunity for personal growth and development.

What you will do

• Design and implement stage appropriate DMPK strategies with AI-first approach, integrate the quantitative pharmacology and overall project strategies.
• Design screening cascade and mechanistic experiments to support project progression in a data-driven manner.
• Integrate DMPK, PD and toxicological data to extract decision-making information, including dose and safety window predictions.
• Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads.
• Optimise molecule design based on physico-chemistry and biotransformation knowledge in collaboration with Chemistry Leads.
• Contribute to data generation and analysis to support AI-based ADME models development.
• Maintain close relationships with CRO network to ensure high quality and timely data generation.
• Maintain knowledge of state-of-the-art technologies and methods to increase confidence in human PK prediction.
• Embrace and champion a culture of inclusion and continuous professional development.

Skills and qualifications

Essential:

• PhD in relevant subject: Pharmaceutical Science, Pharmacy, Chemistry.
• 6+ years of related experience in the pharmaceutical industry.
• Experience as a DMPK Lead of solving DMPK related problems in drug discovery and track record of working collaboratively to deliver high quality candidates.
• In depth knowledge of biotransformation.
• In depth knowledge of PK modelling and scaling of ADME properties.

Nice to have:

• Hands on experience of PBPK and PKPD modelling.
• Good understanding of machine learning techniques.
• Experience with new modalities and peptides.

Culture and values

We are guided by our shared values. It’s not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.