Medicinal Chemist, London, Lausanne

About the Medicinal Drug Design Team

We are a growing, dynamic team of medicinal chemists within the Drug Design and Medical Research function. We drive the medicinal chemistry strategy for our internal portfolio and collaboration projects. Crucially, we partner closely with our AI/ML colleagues, using our domain expertise to enhance the Isomorphic Platform and leverage its power to accelerate drug design. We foster a supportive, learning-focused environment where every member is valued, and continuous professional development is a priority.

Your impact

As part of our expansion, we are excited to hire talented and motivated Medicinal Chemists. This is a fantastic opportunity for scientists early in their careers to enter the exciting field of AI-driven drug discovery.

You will be an integral part of project teams, learning how to apply the latest AI to drug design. Working alongside experienced medicinal chemists within an interdisciplinary team, you will receive dedicated mentorship and gain hands-on experience applying state-of-the-art computational tools to real-world drug discovery challenges. If you are ambitious, eager to learn, and want to apply your chemistry skills in a cutting-edge environment, Isomorphic Labs offers an unparalleled opportunity for growth.

What you will do

• Contribute to Drug Design: Apply your knowledge of synthetic organic and medicinal chemistry to design novel molecules with desirable drug-like properties using the Iso platform.
• Execute Chemistry Strategy: Work closely with senior chemists and CRO partners to plan and execute synthetic routes, troubleshoot synthetic challenges, and ensure timely delivery of target compounds.
• Data Analysis & Interpretation: Analyse and interpret biological and chemical data.
• Collaborate Effectively: Work within multi-disciplinary project teams (including computational chemists, biologists, DMPK scientists, AI/ML researchers) and manage relationships with external CRO chemists under guidance.
• Communicate Science: Prepare clear summaries, reports, and presentations of your work for internal meetings and potentially contribute to documentation for external partners.
• Learn and Grow: Actively seek, and engage in, learning opportunities, embrace feedback, and contribute positively to our inclusive and science-driven culture.

Skills and qualifications

Essential:

• PhD in synthetic organic chemistry, medicinal chemistry or a related technical field, or equivalent experience.
• Strong foundational knowledge of modern synthetic organic chemistry
• Foundational understanding of core medicinal chemistry concepts (e.g. structure-activity relationships and basic ADME/PK principles).
• Demonstrated problem-solving skills and scientific curiosity.
• Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a collaborative team environment.
• A genuine passion for drug discovery and enthusiasm for learning how AI/ML can transform the field.
• A strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to have:

• 1-2 years of relevant postdoctoral or industrial medicinal chemistry experience.
• Experience working with or managing chemistry activities at Contract Research Organisations (CROs).
• Familiarity with computational chemistry tools and techniques (e.g., molecular modeling, data analysis software).
• Knowledge of specific drug discovery approaches like Structure-Based Drug Design (SBDD) or Fragment-Based Drug Design (FBDD).
• Understanding of Drug Metabolism and Pharmacokinetics (DMPK) principles.
• Track record of authorship of relevant scientific manuscripts and inventorship of composition of matter patents.
• Solid understanding of core medicinal chemistry concepts (e.g. structure-activity relationships and basic ADME/PK principles).
• Excited about this opportunity? We encourage you to apply by Friday, May 23rd, 2025.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.