Research Scientist – Oligonucleotide Synthesis

We are looking for a highly motivated individual to join the Oligonucleotide Synthesis Team as a Scientist in Nucleotide Chemistry.

The Details…

In this exciting role you will assist in expanding the  nucleotide and oligonucleotide synthesis capabilities aimed at research and development within a newly established oligonucleotide facility.

Depending on experience, you will take on technical leadership roles and work closely with other members of the oligonucleotide facility team where you will develop new synthesis, purification and analytical methodologies/workflows for a wide range of critical long and modified DNA/RNA oligonucleotides.  Additionally you will play a collaborative role in the decision making of strategic objectives that influence future projects within the team and the company.

Responsibilities include:

• Developing an oligonucleotide synthesis pipeline to serve critical R&D projects.
• Developing synthesis methodologies for complex, modified and long DNA/RNA oligonucleotides.
• Improving purification and analytical workflows for synthesised oligonucleotides, introducing automation where possible.
• Analysing oligonucleotides by high-resolution CE, LC-MS and HPLC.
• Onboarding new technology and methods to improve operational effectiveness and contributing to the scientific and technical training of the team.
• Supporting ambitious and innovative R&D projects.
• Promoting a safe working environment for all team members and a culture of continuous improvement for health & safety.
• Preparing clearly articulated progress reports and keeping well-organised experimental records.
• Working and communicating effectively across a number of research and development groups.

What We’re Looking For…

• BSc, MSc or PhD degree in chemistry with industrial or equivalent experience.
• Experience in oligonucleotide synthesis and bioconjugation.
• Nucleosides, phosphoramidites and triphosphates synthesis experience would be desirable.
• Practical knowledge of small molecules and oligonucleotide analysis and purification.
• Strong problem solving and analytical skills.
• Strong attention to detail and a high level of organisation.
• Training will be provided and, as such, a willingness to learn and develop is essential.

  Applications are encouraged from highly motivated individuals who enjoy taking on new challenges, are quickly adaptable in would thrive working in an exciting and fast-paced environment.