Scientist, Morphological Profiling / High-Content Imaging

Position Description:

Calico is seeking a Scientist to join the Cellular Phenotyping (CP) group. Our lab applies high-content imaging and phenotypic screening to better understand age-related processes and identify opportunities for therapeutic interventions. Your responsibilities will include implementing strategically useful cell culture models and using high-throughput microscopy-based approaches for characterizing cellular phenotypes. This role will require integration of cutting-edge cell culture methods with rapidly evolving approaches to image analysis. The ideal candidate has a broad technical background that will enable effective collaboration between life scientists, data scientists, machine learning engineers and automation engineers. To succeed in this role, you will need to be self-motivated, collaborative and enthusiastic about technology.

Position Requirements:

• Ph.D. degree in biology or bioengineering plus 0-5 years of relevant postdoctoral or industry experience
• Experience with high-content imaging or automated microscopy
• Experience with basic image analysis (segmentation, feature extraction, quantification)
• Track record of productivity and effective collaboration
• Ability to work flexibly in a fast-paced environment with shifting priorities
• Clear verbal and written communication skills
• Attention to detail, time management and organization skills are a must
• Must be willing to work onsite 5 days a week

Nice to Have:

• Advanced tissue culture models including any/all of the following: iPSC-derived disease models, spheroid/organoid models, co-culture systems
• Plate-based phenotypic screening
• CRISPR gene editing methods
• Unbiased profiling technologies such as RNAseq, proteomics or metabolomics
• Common lab automation, such as liquid handling
• Programming in Python and the fundamentals of machine learning concepts

The estimated base salary range for this role is $135,000 – $163,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.