Senior Associate Scientist, Metabolomics

Position Description:

Calico is seeking a highly motivated Senior Associate Scientist to join our team studying cellular and organismal metabolism. The successful candidate will play a key role in investigating metabolic mechanisms underlying aging and age-related disease using state-of-the-art metabolomics techniques, in both cell-based assays and in vivo mouse models. The ideal candidate will have strong technical expertise, excellent analytical skills, and the ability to work both independently and collaboratively in a dynamic research environment.

Responsibilities:

• Design, plan, and execute experiments investigating cellular and organismal metabolism
• Prepare metabolomics and lipidomics samples from tissues, cells, and biofluids and analyze them by LC-MS/MS
• Conduct mammalian tissue culture and perform standard molecular biology techniques (e.g. nucleic acid extraction, western blot, ELISA)
• Assist with in vivo experiments, including handling/monitoring mice, tissue collection
• Analyze and interpret experimental data, prepare figures for, and present at internal meetings
• Maintain accurate and detailed laboratory records in compliance with institutional policies

Position Requirements:

• Bachelor’s or Master’s degree in molecular biology, cell biology, biochemistry, or a related field, with 5+ years of post-Bachelor’s (or 3+ post-Master’s) relevant research experience in an academic or industry setting
• Proficiency in mammalian cell culture, gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods (e.g., nucleic acid extraction, Western blotting)
• Ability to manage multiple projects simultaneously and work independently
• Strong analytical skills and attention to detail
• Excellent communication and organizational skills
• Must be willing to work onsite five days a week

Nice to Have:

• Experience with metabolic assays (e.g. Seahorse analysis) and flow cytometry
• Comfort with data analysis tools (e.g. GraphPad Prism, basic scripting in R/Python)
• Familiarity with mass spectrometry methods (LC-MS, GC-MS) is a plus
• Previous involvement in manuscript preparation or authorship of peer-reviewed publications

The estimated base salary range for this role is $107,000 – $143,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.