Senior Associate Scientist, Protein Sciences

Calico is seeking a Senior Associate Scientist to join our multi-disciplinary Protein Sciences team with a focus on applying biochemistry techniques, protein biophysical characterization and assay development to support projects relevant to human aging and disease. The candidate will work closely with protein biochemists to gain mechanistic understanding of protein targets and potential therapeutics. The ideal candidate must be highly motivated, detail-oriented, work autonomously with a variety of experimental techniques, and be comfortable presenting results to cross-functional teams.

Position Requirements:

• BS/MS in Biochemistry or related discipline, plus 6+ years post-graduate experience working in industry within a similar core function
• Experience with protein-small molecule binding characterization highly preferred
• Experience with high-mid throughput protein binding discovery screening highly preferred
• Strong expertise with protein based biophysical binding and competition assays (Biacore, Octet, ITC, TSA, etc.) and proficiency in handling related instruments
• Experience with biochemical and/or biophysical assays in 96- or 384- well formats is desired (ELISA, TR-FRET, Fluorescence Polarization, etc.)
• Experience with analytical techniques in protein biophysical characterization (Light scattering, LC-MS, HPLC)
• Experience using an electronic notebook
• Strong teamwork and proactive communication skills
• Independent, accountable, meticulous attention to detail, and able to multitask
• Strong communication and organizational skills to interact with collaborators
• Must be willing to work onsite five days per week

Nice to Have:

• Experience with protein purification (affinity, IEX and SEC) and assessing protein purity using SDS-PAGE
• Experience with enzymatic assays and data interpretation
• Experience with protein labeling and conjugation chemistries
• Experience with assay development and automation/liquid handlers

The estimated base salary range for this role is $122,000 – $143,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.